METHODS

Each topical issue, organized by a guest editor who is an expert in the area covered, consists solely of invited quality articles by specialist authors, many of them reviews. Issues are devoted to specific technical approaches with emphasis on clear detailed descriptions of protocols that allow them to be reproduced easily. The background information provided enables researchers to understand the principles underlying the methods; other helpful sections include comparisons of alternative methods giving the advantages and disadvantages of particular methods, guidance on avoiding potential pitfalls, and suggestions for troubleshooting. Methods focuses on rapidly developing techniques in the experimental biological and medical sciences. Some recent thematic issues covered these hot topics: • Chromatin Structure • Editing and investigating genomes with TALE and CRISPR • Tools and Methods for Cellular Localization and Measurements • Recent development in bioinformatics for utilizing omics data • Nucleic Acids Nanotechnology • Systems Biology with Omics Data • Autophagy • Spatial mapping of multi-modal data in neuroscience • Advancing the boundaries of molecular cellular pathology • NGS applications to translational research • Detection and Quantification of Proteins in Clinical Samples Using Mass Spectrometry